Table 4 Relationships of total testosterone and sexual hormone binding globulin (SHBG) levels with the risk of metabolic syndrome.

From: Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone

Total testosterone (ng/dl)

N

Mean ± SD

Adjusted OR (95% CI)

Model 1

Model 2a

Model 3

>75th

153

518.7 ± 54.6

Ref

Ref

Ref

50–75th

154

418.2 ± 20.3

0.83 (0.51–1.36)

0.64 (0.38–1.07)

0.61 (0.35–1.08)

25–50th

154

351.1 ± 19.5

1.26 (0.78–2.04)

0.89 (0.54–1.48)

0.78 (0.45–1.36)

<25th

153

273.2 ± 35.6

1.58 (0.98–2.55)

0.99 (0.59–1.66)

0.86 (0.48–1.52)

P for trend

  

0.021

0.67

0.86

SHBG (nmol/L)

N

Mean ± SD

Model 1

Model 2 b

Model 3

>75th

153

69.1 ± 18.6

Ref

Ref

Ref

50–75th

154

44.5 ± 3.4

1.44 (0.87–2.40)

1.40 (0.84–2.34)

1.35 (0.77–2.34)

25–50th

151

34.6 ± 3.0

1.62 (0.98–2.69)

1.52 (0.90–2.56)

1.53 (0.63–2.01)

<25th

156

24.0 ± 4.5

3.22 (1.96–5.29)

2.91 (1.71–4.95)

2.02 (1.12–3.62)

P for trend

  

<0.001

<0.001

0.038

  1. Abbreviation: SD = standard deviation; OR = odds ratio; CI = confidence interval.
  2. Model 1: adjusted for age, educational level, alcohol drinking and cigarette smoking.
  3. Model 2a: Model 1 plus SHBG level.
  4. Model 2b: Model 1 plus total testosterone level.
  5. Model 3: Model 2 plus body mass index.