Table 6 Relationships of sexual hormone binding globulin (SHBG) with adiponectin and leptin levels

From: Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone

Log10 Adiponectin

N

Mean ± SD

Model 1

Model 2

Model 3

ß (SE)

p-value

ß (SE)

p-value

ß (SE)

p-value

SHBG (nmol/L)

614

43.0 ± 19.4

0.301 (0.001)

<0.001

0.294 (0.001)

<0.001

0.280 (0.001)

<0.001

0–25th

153

24.0 ± 4.5

1

—

1

—

1

—

25–50th

154

34.6 ± 3.0

0.096 (0.027)

0.039

0.094 (0.027)

0.044

0.084 (0.027)

0.073

50–75th

151

44.5 ± 3.4

0.257 (0.027)

<0.001

0.254 (0.028)

<0.001

0.237 (0.028)

<0.001

>75th

156

69.1 ± 18.6

0.343 (0.027)

<0.001

0.341 (0.029)

<0.001

0.321 (0.029)

<0.001

P for trend

   

<0.001

 

<0.001

 

<0.001

Log 10 Leptin

N

Mean ± SD

ß (SE)

p-value

ß (SE)

p-value

ß (SE)

p-value

SHBG (nmol/L)

614

43.0 ± 19.4

−0.197 (0.001)

<0.001

−0.157 (0.001)

<0.001

−0.120 (0.001)

0.003

0–25th

153

24.0 ± 4.5

1

—

1

—

1

—

25–50th

154

34.6 ± 3.0

−0.098 (0.028)

0.041

−0.083 (0.028)

0.086

−0.054 (0.027)

0.242

50–75th

151

44.5 ± 3.4

−0.176 (0.028)

<0.001

−0.144 (0.029)

0.004

−0.097 (0.028)

0.045

>75th

156

69.1 ± 18.6

−0.273 (0.028)

<0.001

−0.232 (0.030)

<0.001

−0.178 (0.029)

<0.001

P for trend

   

<0.001

 

<0.001

 

<0.001

  1. Abbreviation: SD = standard deviation; SE = standard error; OR = odds ratio; CI = confidence interval.
  2. Model 1: adjusted for age, educational level, alcohol drinking, and cigarette smoking.
  3. Model 2: Model 1 plus total testosterone level.
  4. Model 3: Model 2 plus body mass index.
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