Table 4 Univariate and multivariate analysis of clinical parameters, cytokines with histological activity index in HBeAg (−) patients with normal ALT levels (n = 95).

From: Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase

Parameters

Univariate analysis

P Value (Univariate)

Multivariate analysis

P Value (Multivariate)

HAI < 5 (n = 60)

HAI ≥ 5 (n = 35)

Odds Ratio (95% CI)

Sex distribution, males

65% (39/60)

60% (21/35)

0.66

  

age, years

39.68 ± 11.54

37.89 ± 9.23

0.64

  

BMI (kg/m2)

22.95 ± 2.62

22.43 ± 2.54

0.24

  

HBsAg (log10 IU/ml)

3.66 ± 0.92

3.43 ± 0.57

0.33

  

HBV DNA (log10 IU/ml)

4.34 ± 1.33

4.57 ± 2.02

0.58

  

Anti-HBc (log10 IU/ml)

3.81 ± 1.02

4.79 ± 0.64

<0.001

5.40 (1.91–15.29)

<0.001

ALT (U/L)

26.78 ± 8.22

28.8 ± 9.17

0.2

  

AST (U/L)

25.65 ± 10.35

30.67 ± 11.29

0.004

1.01 (0.99–1.09)

0.13

ALP (U/L)

75.07 ± 26.11

79.85 ± 24.29

0.35

  

GGT (U/L)

26.74 ± 27.54

44.61 ± 41.07

<0.001

1.01 (0.99–1.03)

0.45

Tbil

15.16 ± 7.38

26.88 ± 67.82

0.84

  

Albumin

45.21 ± 4.54

44.34 ± 6.66

0.21

  

PT s

12.36 ± 1.41

12.29 ± 1.45

0.62

  

PTA %

99.59 ± 15.91

97.94 ± 13.19

0.93

  

INR

1.00 ± 0.09

1.02 ± 0.10

0.63

  

Platelet counts (x109/L)

172.2 ± 48.31

160.0 ± 58.75

0.07

  
  1. MBI, body mass index; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; anti-HBc, hepatitis B core antibody; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; Tbil, total bilirubin; PT, prothrombin time; PTA, prothrombin time activity; INR, international normalized ratio.
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