Figure 5 | Scientific Reports

Figure 5

From: Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage

Figure 5

Inhibition of Wnt signaling in Axin2-expressing cells impairs reparative dentinogenesis. Real-time qPCR analysis of Wls gene expression in dental pulp tissue extracted from WT and Wlsfl/fl mice teeth 5 days post-damage (A) Masson’s Trichrome staining of a damaged superior first molar from WT mice (B), Wlsfl/fl mice (C) and Axin2CreERT2;Wlsfl/fl mice 14 days post-damage (D). Representative sagittal sections are shown, scale bars are equivalent to 100 μm, an arrow indicates the site of damage and an asterisk indicates a dentine bridge. Quantification of PCNA positive cells in damaged superior first molar from WT and Axin2CreERT2; Wlsfl/fl mice post-damage (E), n = 4, *p = <0.05.

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