Figure 2 | Scientific Reports

Figure 2

From: Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes

Figure 2

LPS-induced changes in the expression of inflammatory cytokines. Shown are the relative mRNA expression levels of different cytokines after LPS treatment in increasing concentrations for 6 h (white bar) and 48 h (gray bar). 6 hours treatment increased mRNA expression of pro-inflammatory factors IL1 (A), IL8 (E), CCL2 (F), and CCL5 (G), while prolonged treatment (48 h) enhanced expression of anti-inflammatory genes of IL10 (B). TNFα (C) and IL6 (D) were increased by LPS-treatment for both 6 h and 48 h. Main LPS-receptor TLR4 (H) was time-independently raised by LPS-treatment. p-values (One-way ANOVA) for 6 h- and 48 h-treatment (6 h/48 h): CCL2: 0.008/0.0156; CCL5: 0.0855/0.001; IL-1b: 0.0038/ < 0.0001; IL-6: <0.0001/0.0002; IL-8: 0.0008/0.005; TLR4: 0.0021/0.0011; TNF-α: 0.0012/0.0171; IL-10: 0.0010/0.0072.

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