Figure 7
LPS-treatment attenuated SK1-3 channel currents (ISK1-3). Membrane currents were recorded in absence and presence of 100 nM apamin (A and B) or 10 µM NS8593 (C and D), blockers of SK1-3 channels. The blocker-sensitive currents were analyzed as ISK1-3. (A) Current-voltage (I–V) relationship curves of apamin-sensitive currents recorded from −80 to +80 mV with the holding potential of −80 mV. (B) Mean values of apamin-sensitive currents at +40 mV. (C) I–V curves of NS8593-sensitive currents. (D) Mean values of NS8593-sensitive currents at +40 mV. Values given are mean ± SEM. n, number of cells. *p < 0.05, **p < 0.01.
