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Figure 1

From: Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation

Figure 1

Transmission of DC and CR after γ-ray 4 Gy 137Cs irradiation following TC staining. We plotted the mean frequency of CAs for three donors, as well as the individual values for each donor. (A) TC staining improved the detection of different DCs configurations when the centromere was in close proximity to or in contact with the telomeres (DC-B) and when both centromeres in close proximity (DC-C). It was possible to easily distinguish centric and acentric rings. We detected AC (+/+) with 4 telomeres resulting from a fusion event generally accompanying the formation of a DC or CR; AC (+/−) with 2 telomeres representing terminal deletions; AC(−/−)without telomeres representing interstitial deletions and telomere chromosome deletion (Chr (+/−)). (B) The transmission of DC and CR: The decrease in the transmission frequency of DCs by cell division was greater than that of CRs. (C) The frequency of complete and incomplete DC and RC transmission by cell division. (D) The frequency of various DC configurations in M1 and ≥M3 cells.

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