Figure 2 | Scientific Reports

Figure 2

From: Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation

Figure 2

Transmission of different types of ACs. (A) The frequency of AC (+/+) and terminal deletions (AC (+/−)) decreased by cell division. The frequency of interstitial deletions (AC (−/−)) and the telomere deletions (Chr (+/−)) increased between M1 and M2. (B–D) Sequential analysis by TC staining and M-FISH revealed the presence of pairs of AC (+/+) and AC (−/−) associated with DCs and RC (E-a) with breakpoints near the centromeric region and the formation of DC(10;17) accompanied by a pair of AC(10;17) (+/+) (E-b) The presence of a pair of AC(14;20)(+/+) in M2 cells with centromere sequences, demonstrating that the breakpoints were in the centromeric region and associated with the presence of DC(14;20) with the two centromeres in close proximity. (E-c) the presence of small rings characterized by the two breakpoints near the centromeric region associated to the formation of pair AC(3;3) (+/+). (E-d) DC(4;21) without the pair of AC(+/+) was characterized by the breakpoints not localized within the centrometric region.

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