Figure 4 | Scientific Reports

Figure 4

From: Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation

Figure 4

Donor-dependent frequency of giant cells in M2 after TC staining. (A) The high frequency of induced CAs, DCs, CR, and ACs (AC (+/+) and AC (−/−)) revealed by sequential analysis using TC staining and M-FISH demonstrates the presence of a pair of DCs, CR, and ACs, indicating replication of these aberrations during cell division. (B) Telomere deletion appears to play a major role in the formation of complex chromosomal rearrangements and the progression of chromosomal instability (C) the classification of chromosome demonstrated the complexity of induced aberrations (D) Giant M2 cell characterized by fewer unstable CAs, but a higher frequency of telomere deletions (yellow arrow). Chromosome pulverization was observed (red arrow).

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