Figure 5 | Scientific Reports

Figure 5

From: Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α V β 3 Integrin Activity

Figure 5

Dynamic PET-CT images (A) were used to plot the blood clearance (B) and time activity curves (TAC) of 64Cu-NOTA-PEG4-cRGD2 in selected organs (C). (D) Biodistribution of 64Cu-NOTA-PEG4-cRGD2 in selected organs at 90 min post-injection in Lewis rats subjected to myocardial infarction induced by surgical ligation of LAD. Results are expressed in percentage of injected dose per gram tissue (%I.D./g). These results suggest a rapid blood clearance through renal filtration and very low non-specific uptake in other critical organs.

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