Table 2 List of the selected candidate genes and polymorphisms.
From: Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility
Symbol | Gene | SNP ID | Alleles | Frequency | HWE P value |
|---|---|---|---|---|---|
OPRM1 | Opioid receptor, mu 1 | rs1799971 | A/G | 0.32 | 1 |
CYP1A2 | Cytochrome P450 family 1 subfamily A member 2 | rs2470890 | C/T | 0.13 | 0.99 |
NOS3 | nitric oxide synthase 3 | rs2070744 | C/T | 0.08 | 0.568 |
GR1N3A | NMDA receptor 3A subunit gene | rs3739722 | C/T | 0.39 | 0.852 |
GR1N2B | NMDA receptor 2B subunit gene | rs3764028 | G/T | 0.16 | 0.675 |
5HT2A | 5-Hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | rs6313 | A/G | 0.49 | 0.169 |
GABRB2 | Gamma-aminobutyric acid (GABA) A receptor, beta 2 | rs2229944 | A/G | 0.06 | 0.571 |
GABRA6 | Gamma-aminobutyric acid (GABA) A receptor, alpha 6 | rs3219151 | C/T | 0.32 | 0.861 |
GABRA1 | Gamma-aminobutyric acid (GABA) A receptor, alpha 1 | rs2279020 | A/G | 0.19 | 0.971 |
GABRG2 | Gamma-aminobutyric acid (GABA) A receptor, gamma 2 | rs211014 | A/C | 0.45 | 0.764 |
rs211013 | A/G | 0.29 | 0.847 | ||
GABRA2 | Gamma-aminobutyric acid (GABA) A receptor, alpha 2 | rs279858 | C/T | 0.45 | 0.762 |
rs567926 | A/G | 0.49 | 0.626 | ||
rs11503014 | C/G | 0.08 | 0.578 | ||
Calcium channel | Calcium channel | Â | Â | Â | Â |
rs3846446 | A/C | 0.38 | 0.89 | ||
KCNS1 | Potassium channel alpha subunit | rs734784 | C/T | 0.20 | 0.95 |
rs2070995 | C/T | 0.36 | 0.966 | ||
SCN9A | Sodium channel | rs6746030 | A/G | 0.06 | 0.982 |
OPRD1 | Opioid receptor, delta 1 | rs223686 | G/T | 0.04 | 1 |
ABCB1 | ATP-binding cassette, subfamily B, member 1 | rs1045642 | A/G | 0.40 | 0.97 |
GAL | Galanin | rs948854 | C/T | 0.16 | 0.667 |
TAOK3 | TAO kinase 3 | rs795484 | C/T | 0.49 | 0.979 |
FAM53B | Family with sequence similarity 53 member B | rs2629540 | C/G | 0.27 | 0.5 |
CHRNA5 | Cholinergic receptor, nicotinic alpha 5 | rs16969968 | A/G | 0.02 | 1 |
ADRB1 | Adrenoceptor beta 1 | rs1801253 | None | Â | Â |
rs737866 | C/T | 0.30 | 0.344 | ||
COMT | Catechol-O-methyltransferase | rs4680 | A/G | 0.24 | 0.618 |
rs174696 | C/T | 0.41 | <0.001 | ||
ADH4 | Alcohol dehydrogenase 4 (class II), pi polypeptide | rs1042363 | T | 0 | 1 |
rs1229984 | C/T | 0.29 | 1 | ||
rs1126671 | C/T | 0.23 | 0.01 | ||
rs978437 | C/T | 0.49 | 1 | ||
CHRM2 | Cholinergic receptor, muscarinic 2 | rs1455858 | C/T | 0.45 | 0.888 |
rs1824024 | A/C | 0.49 | 0.89 | ||
rs324650 | A/T | 0.09 | 1 | ||
rs2283265 | A/C | 0.41 | 0.969 | ||
DAT | Dopamine transporter | rs1076563 | A/C | 0.08 | 1 |
DRD2 | Dopamine receptor D2 | rs2587548 | C/G | 0.09 | 1 |
rs9288993 | A | 0 | 1 | ||
rs2654754 | A/G | 0.01 | 1 | ||
DRD3 | Dopamine receptor D3 | rs6454674 | None | Â | Â |
rs806368 | C/T | 0.50 | 0.474 | ||
CNR1 | Cannabinoid receptor 1 | rs324419 | C/T | 0.13 | <0.001 |
rs2295633 | A/G | 0.20 | 0.747 | ||
FAAH | Fatty acid amide hydrolase | rs2835859 | C/T | 0.14 | 0.002 |
rs1534891 | C/T | 0.09 | 0.807 | ||
GIRK | Potassium channel, inwardly rectifying subfamily J, member 3 | rs6001093 | C/T | 0.08 | 0.574 |
CSNK1E | Casein kinase 1 epsilon | rs135757 | A/G | 0.15 | 0.925 |
rs2734849 | A/G | 0.10 | 0.988 | ||
rs2708092 | A/G | 0.46 | 0.766 | ||
ANKK1 | Ankyrin repeat and kinase domain containing 1 | rs1180012 | C/T | 0.16 | 0.72 |
P2RX7 | Ligand-gated ion channel | rs1718125 | C/T | 0.49 | 0.482 |
rs208293 | C/T | 0.42 | 0.971 | ||
rs1718136 | A/G | 0.13 | 0.536 | ||
rs7132846 | C/T | 0.18 | 0.94 | ||
rs7958311 | A/G | 0.49 | 0.477 | ||
rs3751143 | A/C | 0.17 | 0.725 | ||
rs208294 | C/T | 0.37 | 0.469 |
