Figure 4
From: REG3β modifies cell tumor function by impairing extracellular vesicle uptake
Impaired metabolic switch in the three main cell types of tumor microenvironment due to EV blockage by REG3β. Metabolomic analysis of those metabolites which the REG3β-blocking of signal transduction through EVs prevented increases or decreases in their dysregulation. Heatmaps of metabolites grouped according to their chemical class in order to illustrate the most frequent altered families by this blocking mechanism. AA (aminoacids), AC (acylcarnitines), Carbs (carbohydrates), CBA (carboxylic acids), GL (glycerolipids), GPL (glycerophospholipids), NEFA (non-esterified fatty acids), ns (nucleosides), nt (nucleotides), Pu (purines), Pyr (pyrimidines), SL (sphingolipids).
