Table 1 Systemic inflammatory markers in obese pre-diabetic LH-21-treated mice.

From: The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice

Systemic Inflammatory Markers

CONTROL

45% HFD VEH

45% HFD LH-21

Leptin (pg/ml)

4121 ± 749

19550 ± 8501**

13720 ± 7917*

HMWAdiponectin (ng/ml)

5397 ± 2679

2864 ± 746*

2942 ± 1100*

IL-6 (pg/ml)

51,7 ± 13,0

211,4 ± 107,6*

183,4 ± 165,9*

CXCL1 (pg/ml)

137,8 ± 29,9

383,9 ± 209,8*

232,4 ± 169,5

IL-5 (pg/ml)

5,46 ± 1,78

8,99 ± 4,26

12,95 ± 11,67

IL-2 (pg/ml)

5,31 ± 1,59

5,20 ± 1,03

5,56 ± 1,46

IL-12 p70 (pg/ml)

61,41 ± 10,53

78,09 ± 19,51

95,73 ± 31,61

IL-10 (pg/ml)

23,23 ± 16,48

22,45 ± 11,86

26,11 ± 11,12

IFN-γ (pg/ml)

1,31 ± 0,71

1,45 ± 0,44

1,77 ± 0,68

  1. The levels of leptin and HMW adiponectin in plasma were measured with a commercial ELISA. A mouse pro-inflammatory panel kit was used for the quantitative determination of IFN-γ, IL-2, IL-5, IL-6, CXCL1, IL-10 and IL-12p70 by multi-array electrochemiluminescence detection technology. n = 8–10 mice each group. One-way ANOVA and Bonferroni’s post-test, *p < 0.05, **p < 0.01 versus control.
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