Figure 1 | Scientific Reports

Figure 1

From: Discordance in HER2 Status in Gastro-esophageal Adenocarcinomas: A Systematic Review and Meta-analysis

Figure 1

Flow chart of eligible studies for meta-analysis. Strict definition of HER2 assessment: HER2 positivity defined as IHC score 3+ or IHC score 2+ with an amplification of the HER2/neu gene by in situ hybridization (ISH). Broad definition: include IHC scores 2+ and 3+ marked HER2 positive (irrespective of ISH) or amplification of the HER2/neu gene without additional IHC analysis. Mix: Include data of both strict and broad definitions of HER2 status determination; articles used in pair-wise meta-analyses.

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