Figure 2 | Scientific Reports

Figure 2

From: Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury

Figure 2

CCI-TBI induces ROS free radical production in ipsilateral cortex area of injury. In vivo dihydroethidium staining detection in naive (A) vs. 4 hrs following CCI-TBI (B) cerebral cortex in area of CCI-TBI impact site (4X). Red fluorescence indicates oxidation of dihydroethidium and in situ ROS free radical detection. The impact site and affected ipsilateral cortical tissue is outlined with a white dotted line. ROS detection extends through and beyond the depth of the cortex. (C) Quantification of dihydroethidium fluorescence intensity in naive compared to CCI-TBI groups at 4 hrs post-injury. Data are presented as mean ± SD. (Two-tailed unpaired t test with equal SD P = 0.0002, t = 12.83, df = 4).

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