Figure 2

ABCC8 mutation decreased the insulin secretion rate in low and high potassium medium. (A) The fold change of C-peptide content after incubation in low K⁺ and high K⁺ medium compared with normal K⁺ medium. Wild-type, heterozygous mutated and homozygous mutated cells exhibited similar changes. (B) Insulin secretion rate in normal K⁺ medium (KRBH). Wild-type and ABCC8-deficient cells had similar secretion rates. (C) Insulin secretion rate in low K⁺ medium. ABCC8 mutation decreased the insulin secretion rate in low K⁺ medium. (D) Insulin secretion rate in high K⁺ medium. ABCC8 mutation decreased the insulin secretion rate in high K⁺ medium.