Table 1 Association of rs2129979 and its three fully correlated variants with appendicitis in Iceland and the Netherlands. The minor and major alleles are the same in Iceland and the Netherlands, and all effects are presented for the minor allele. A chi-square test was used to compute P-values.
From: Sequence variant at 4q25 near PITX2 associates with appendicitis
Marker* | Position | Allele (min/maj) | Iceland (7,427 cases, 340,069 controls) | The Netherlands (1,139 cases, 4,587 controls) | Combined (8,566 cases, 344,656 controls) | Relation to rs2129979 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF (%) | OR (95% CI) | P | MAF (%) | OR (95% CI) | P | OR (95% CI) | P | Distance (bp) | r2 ICE | |||
rs2129979 | chr4:110799841 | G/T | 29.3 | 1.14 (1.09, 1.19) | 3.5 × 10−9 | 27.7 | 1.19 (1.07, 1.32) | 1.1 × 10−3 | 1.15 (1.10, 1.20) | 1.8 × 10−11 | — | — |
rs11931959 | chr4:110798529 | G/A | 29.3 | 1.14 (1.09, 1.19) | 3.9 × 10−9 | 27.7 | 1.19 (1.07, 1.32) | 1.0 × 10−3 | 1.15 (1.10, 1.20) | 2.1 × 10−11 | 1,589 | 1.00 |
rs2171591 | chr4:110798252 | A/G | 29.3 | 1.14 (1.09, 1.19) | 4.0 × 10−9 | 27.7 | 1.19 (1.07, 1.32) | 1.1 × 10−3 | 1.15 (1.10, 1.20) | 2.1 × 10−11 | 1,459 | 1.00 |
rs17042195 | chr4:110798382 | C/G | 29.3 | 1.14 (1.09, 1.19) | 4.1 × 10−9 | 27.7 | 1.19 (1.07, 1.32) | 1.1 × 10−3 | 1.15 (1.10, 1.20) | 2.2 × 10−11 | 1,312 | 1.00 |
