Figure 2

K ^trans, V _e maps and photomicrographs of five renal tumor types. (a) A 46-year-old male with ccRCC. (a1) K ^trans value of ccRCC was 0.372 min⁻¹; (a2) V _e value of ccRCC was 0.497; (a3) H&E staining (original magnification, 20×) shows solid alveolar and acinar patterns arranged by tumor cells with a clear cytoplasm and a regular network of small thin-walled blood vessels.; (a4) Immunohistochemistry for CD31 (original magnification, 20×) shows a network of small, thin-walled blood vessels. (b) A 45-year-old male with pRCC. (b1) K ^trans value of pRCC was 0.094 min⁻¹; (b2) V _e value of pRCC was 0.213; (b3) H&E staining (original magnification, 20×) shows papillae formed by delicate fibrovascular cores that contain foamy macrophages. Papillae are lined with cytologically low-grade cells with a small amount of cytoplasm and relatively uniform nuclei; (b4) Immunohistochemistry CD31 (original magnification, 20×) shows small, delicate blood vessels in the fibrovascular cores, but not between the papillae. (c) A 49-year-old male with cRCC. (c1) K ^trans value of cRCC was 0.259 min⁻¹; (c2) V _e value of cRCC was 0.439; (c3) H&E staining (original magnification, 20×) shows tumor cells arranged in a solid sheet-like pattern, separated by incomplete, hyalinized vascular septa. Tumor cells are round to polygonal and have well-defined cytoplasmic borders, pale eosinophilic cytoplasm with a fine reticular pattern, and perinuclear halos; (c4) Immunohistochemistry CD31 (original magnification, 20×) shows positively stained endothelial cells lining the surface of incomplete and hyalinized vascular septa. (d) A 67-year-old male with UEC. (d1) K ^trans value of UEC was 0.203 min⁻¹; (d2) V _e value of UEC was 0.498; (d3) H&E staining (original magnification, 20×) shows infiltrating cohesive nests of cells with moderate-to-abundant amphophilic cytoplasm and large hyperchromatic nuclei. Irregular blood vessels of different sizes and thicknesses in stroma between tumor cell nests; (d4) Immunohistochemistry CD31 (original magnification, 20×) shows positively stained endothelial cells lining irregular blood vessels in the stroma. (e) A 46-year-old female with fpAML. (e1) K ^trans value of fpAML was 0.607 min⁻¹; (e2) V _e value of fpAML was 0.570; (e3) H&E (original magnification, 20×) shows tumor composed of various mixtures of thick-walled and poorly organized blood vessels, smooth muscle and rare mature fat; (e4) IHC CD31 (original magnification, 20×) shows thick-walled poorly organized blood vessels.