Figure 3
From: Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development
Myf5-Cre driven COUP-TFII overexpression impaired skeletal muscle development in vivo. (A) Phenotypical differences of control littermate (CTRL) and My5-COUP-TFIIOE/+ fetus. (B) Fixed and de-skinned fetus under dissection microscope. Bold arrow: body wall; dotted arrow: ribs. (C) H&E staining of dorsal trunk, abdomen and tongue muscles, sequentially. Bold arrow: the thickness of psoas major muscle; dotted arrow: abdomen muscle; ∆ spinal cord; *umbilical ring. Enlarged square area of the tongue was shown on the bottom right site. (D) Dissection microscope imaging of whole diaphragm and H&E staining was shown in right panel. Animals were delivered by cesarean section on the 18th day of gestation.
