Table 1 Microarray data pre- and post-FR treatment showing 40 of the most up- and down-regulated genes and their fold change in response to FR versus control treatment. AnxA8 was one of the most down-regulated genes, while AnxA7 was almost unchanged. The neuronal marker calretinin was up-regulated in FR-treated ARPE-19 cells.
From: Regulation of retinal pigment epithelial cell phenotype by Annexin A8
Probe ID | Gene symbol | Gene name | Fold change | P value |
|---|---|---|---|---|
206658_at | UPK3B | uroplakin 3B | −6.94642 | 1.38E-07 |
206758_at | EDN2 | endothelin 2 | −5.78156 | 2.48E-08 |
211029_x_at | FGF18 | fibroblast growth factor 18 | −5.67398 | 7.78E-10 |
219054_at | C5orf23 | chromosome 5 open reading frame 23 | −5.44576 | 5.92E-08 |
211959_at | IGFBP5 | Insulin-like growth factor binding protein 5 | −5.27773 | 4.60E-06 |
203074_at | ANXA8 | annexin A8 | −4.63574 | 5.14E-10 |
219790_s_at | NPR3 | natriuretic peptide receptor | −4.3291 | 1.96E-07 |
219937_at | TRHDE | thyrotropin-releasing hormone degrading enzyme | −3.9654 | 1.49E-07 |
223063_at | C1orf198 | chromosome 1 open reading frame 198 | −3.75853 | 2.50E-08 |
201564_s_at | FSCN1 | fascin homolog 1 | −3.67614 | 2.37E-07 |
209292_at | ID4 | Inhibitor of DNA binding 4 | −3.6008 | 2.31E-09 |
204451_at | FZD1 | frizzled homolog 1 (Drosophila) | −3.28944 | 4.37E-08 |
228885_at | RPL24 | ribosomal protein L24 | −3.24399 | 1.39E-07 |
218931_at | RAB17 | RAB17, member RAS oncogene family | −3.20924 | 2.18E-09 |
20364_s_at | COBLL1 | COBL-like 1 | −3.18439 | 1.64E-07 |
207787_at | KRT | keratin 33B | −3.14621 | 2.54E-07 |
217841_s_at | PPME1 | protein phosphatase ethyl esterase 1 | −2.7241 | 1.16E-07 |
240890_at | CASP4 | caspase 4 | −2.63728 | 3.68E-09 |
212158_at | SDC2 | syndecan 2 | −2.55582 | 9.17E-08 |
209082_s_at | Col18A1 | collagen type XVII | −2.01389 | 1.19E-07 |
201366_at | ANXA7 | annexin A7 | 1.38439 | 5.73E-06 |
205428_s_at | CALB2 | calbindin 2 (calretinin) | 2.87484 | 1.24E-05 |
209278_s_at | TFPI2 | tissue factor pathway inhibitor 2 | 2.93228 | 5.23E-08 |
201425_at | ALDH2 | aldehyde dehydrogenase 2 family | 2.94253 | 1.27E-07 |
214453_s_at | IFI44 | interferon-induced protein 44 | 3.172 | 7.16E-07 |
205110_at | FGF13 | fibroblast growth factor 13 | 3.25386 | 1.78E-08 |
205047_at | ASNS | asparagine synthetase | 3.30353 | 4.79E-08 |
223062_s_at | PSAT1 | phosphoserine aminotransferase 1 | 3.31132 | 7.38E-07 |
214430_at | GLA | galactosidase, alpha | 3.39277 | 2.68E-06 |
205730_s_at | ABLIM3 | actin binding LIM protein family, member 3 | 3.45524 | 6.46E-07 |
205479_s_at | PLAU | plasminogen activator, urokinase | 3.51411 | 1.38E-06 |
238133_at | NTNG1 | netrin G1 | 3.52826 | 1.64E-06 |
213112_s_at | SQSTM1 | sequestosome 1 | 3.87001 | 1.03E-06 |
208025_s_at | HMGA2 | high mobility group AT-hook 2 | 4.14352 | 5.32E-07 |
212298_at | NRP1 | neuropilin 1 | 4.62486 | 4.84E-06 |
203505_at | ABCA1 | ATP-binding cassette | 5.71048 | 7.09E-08 |
202859_x_at | IL8 | interleukin 8 | 6.38496 | 1.64E-07 |
211506_s_at | IL18 | interleukin 18 | 6.42257 | 1.07E-08 |
206172_at | IL13RA2 | interleukin 13 receptor, alpha 2 | 6.44241 | 2.16E-07 |
219926_at | POPCD3 | Popeye domain containing 3 | 6.82434 | 8.44E-08 |
