Figure 3
From: c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKs
Imatinib mesylate administration led to defects in muscularis propria of the GI tract. (a) Administration of imatinib mesylate inhibited c-Abl activation in esophagus and colon tissues, manifested by a decrease in the phosphorylation of c-CRKL, a phosphorylation substrate of Abl kinases. N = 3. (b) Representative histological sections of the esophagus in imatinib mesylate-treated and control mice. The organs were paraffin-embedded and the section slides were stained with Hematoxylin and eosin. N = 3. (c) High magnification: representative histological sections of the esophagus in imatinib mesylate-treated and control mice. The organs were paraffin-embedded and the section slides were stained with Hematoxylin and eosin. N = 3. (d) Representative histological sections of the stomach in imatinib mesylate-treated and control mice. The organs were paraffin-embedded and the section slides were stained with Hematoxylin and eosin. N = 3. (e) Representative histological sections of the rectum in imatinib mesylate-treated and control mice. The organs were paraffin-embedded and the section slides were stained with Hematoxylin and eosin. N = 3.
