Figure 2
From: Methylation of DACT2 promotes breast cancer development by activating Wnt signaling
Representative MSP and IHC results of DACT2 in human primary breast cancer (A) Representative MSP results of DACT2 in normal breast tissues (N1, N2, N3, N4 and N5) and primary breast cancer tissues (BC). (B) Representative IHC staining of DACT2 in breast cancer (left panels) and adjacent tissue (right panels). Upper panels: 100×; lower panels: 400×. (C) DACT2 expression scores are shown as box plots. The bottom and top of the boxes represent the 25th and 75th percentiles, respectively; vertical bars represent the range of data. The levels of expression are higher in adjacent tissue compared to cancer samples. ***P < 0.001 (D) The levels of DACT2 expression and DNA methylation status are shown as bar diagram. Reduced expression of DACT2 was significantly associated with promoter region hypermethylation. *P < 0.05.
