Table 1 Baseline characteristics of the patients.

From: C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

Variables

All (n = 195)

Non-carriers (n = 151)

Carriers (n = 44)

p

Age (years)

72.9 ± 9.6

73.4 ± 9.1

71.0 ± 10.9

0.143

Women (%)

38.5

35.8

47.7

0.163

CHA2DS2 VASc score

2.4 ± 1.5

2.5 ± 1.5

2.3 ± 1.5

0.444

Paroxysmal AF (%)

32.3

31.1

36.4

0.583

Time in therapeutic range (%)

61.4 ± 19.6

61.7 ± 19.0

60.3 ± 21.3

0.669

Arterial Hypertension (%)

86.2

85.4

88.6

0.804

Diabetes mellitus (%)

17.9

16.6

22.7

0.374

Heart failure (%)

14.4

12.6

20.5

0.222

History of ischemic stroke/TIA (%)

17.7

18.8

14.0

0.650

History of cardiac events (%)

19.3

19.5

18.6

0.900

Ejection fraction (%)

54.6 ± 8.4

54.9 ± 7.9

53.4 ± 10.3

0.378

Left atrium diameter (mm)

44.3 ± 6.0

44.3 ± 5.9

44.1 ± 6.2

0.889

C-reactive protein (mg/dl)

0.22 [0.13–0.41]

0.22 [0.12–0.40]

0.23 [0.15–0.50]

0.567

NT-proANP (pg/ml)

57.5 [50.7–85.4]

61.7 [51.0–89.3]

52.3 [48.1–70.0]

0.040

Antiplatelet therapy (%)

9.2

10.6

4.5

0.373

Diuretics (%)

41.0

41.1

40.9

0.986

Statins (%)

31.3

31.1

31.8

0.931

RAS inhibitors (%)

60.5

58.9

65.9

0.484

  1. Continuous data are expressed as mean ± SD or as median with interquartile ranges (CRP and NT-proANP). RAS: Renin-Angiotensin System; TIA: transient ischemic attack; AF: atrial fibrillation.