Table 1 The impact of obesity on T cell subsets in the peripheral blood and bone marrow of OA patients.

From: IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity

Ā 

Normal weight (BMI 18.5–24.9)

Obese (BMI ≄ 30.0)

PB

BM

PB

BM

CD4:CD8 ratio

2.7 ± 0.8

0.7 ± 0.1

2.9 ± 0.6

1.4 ± 0.3

CD4 + T cells

Ā % TN

45.5 ± 6.6

25.8 ± 5.8

43.3 ± 3.8

31.4 ± 4.3

Ā % TCM

34.3 ± 3.6

31 ± 5

40.9 ± 3.2

33.7 ± 2.7

Ā % TEM

14.1 ± 4.3

38.9 ± 4.8

13.9 ± 1.8

32.3 ± 3.4

Ā % TEMRA

5.4 ± 1.2

4.3 ± 1

3.3 ± 1.2

2.7 ± 0.4

Ā % CD28āˆ’

1.5 ± 0.6

1.7 ± 0.4

1.1 ± 0.4

1.3 ± 0.4

Ā % CD69+

0.2 ± 0.1

15.3 ± 1.9

0.4 ± 0.2

15.2 ± 2.5

Ā % Treg

3 ± 0.4

3.3 ± 0.7

3.5 ± 0.9

3 ± 0.4

 % IFN-γ+

19.2 ± 3.4

31.7 ± 6

10.1 ± 1.9

21.2 ± 6.2

Ā % IL-4+

3.7 ± 1.1

3.4 ± 0.9

2.4 ± 0.7

1.6 ± 0.7

Ā % IL-2+

59.7 ± 5.1

47.4 ± 8.7

55.1 ± 5.7

32.5 ± 8.3

Ā % IL-10+

0.38 ± 0.06

1.6 ± 0.6

0.29 ± 0.05

1.7 ± 0.2

Ā % IL-17A+

0.34 ± 0.11

0.67 ± 0.32

0.77 ± 0.12

1.14 ± 0.16

 % IL-17A+ IFN-γ+

0.01 ± 0.004

0.14 ± 0.06

0.09 ± 0.05

0.39 ± 0.08

Ā % polyfunctional

10.9 ± 1.3

19.8 ± 4.2

6.3 ± 1.3

10.8 ± 6.6

CD8 + T cells

Ā % TN

14.8 ± 5.5

6.3 ± 0.9

12.3 ± 2.4

8.6 ± 1.3

Ā % TCM

15.3 ± 2.6

12.3 ± 3.9

19.9 ± 3.9

14 ± 1.7

Ā % TEM

37.2 ± 6.1

51.6 ± 2.4

38.2 ± 7.2

50.5 ± 3.9

Ā % TEMRA

32.7 ± 4.5

29.7 ± 5

29.6 ± 4.6

26.9 ± 3.4

Ā % CD28āˆ’

46.7 ± 9.8

32.5 ± 4.1

43.2 ± 10.5

32.3 ± 6.1

Ā % CD28āˆ’ CD57+

28.1 ± 10.8

6.5 ± 3.1

33.5 ± 8.9

11.5 ± 4.9

Ā % CD69+

1.1 ± 0.3

44.4 ± 5.8

1.5 ± 0.3

52.1 ± 5.6

 % IFN-γ+

47.8 ± 10.4

54 ± 9.6

49.7 ± 9.5

64.2 ± 11.3

Ā % IL-2+

22.1 ± 6.6

21.4 ± 7.1

19.6 ± 5.5

22.1 ± 7.6

Ā % polyfunctional

13.9 ± 2.8

19.3 ± 4.3

11 ± 3.5

22.9 ± 1.6

  1. Data are expressed as mean ± SEM. Treg cells were defined as CD25hi CD127dim cells. Polyfunctionality was defined as cells that simultaneously produced IFN-γ, TNF-α and IL-2. PB = peripheral blood; BM = bone marrow.