Table 1 The impact of obesity on T cell subsets in the peripheral blood and bone marrow of OA patients.
Ā | Normal weight (BMI 18.5ā24.9) | Obese (BMIāā„ā30.0) | ||
---|---|---|---|---|
PB | BM | PB | BM | |
CD4:CD8 ratio | 2.7ā±ā0.8 | 0.7ā±ā0.1 | 2.9ā±ā0.6 | 1.4ā±ā0.3 |
CD4 + T cells | ||||
Ā % TN | 45.5ā±ā6.6 | 25.8ā±ā5.8 | 43.3ā±ā3.8 | 31.4ā±ā4.3 |
Ā % TCM | 34.3ā±ā3.6 | 31ā±ā5 | 40.9ā±ā3.2 | 33.7ā±ā2.7 |
Ā % TEM | 14.1ā±ā4.3 | 38.9ā±ā4.8 | 13.9ā±ā1.8 | 32.3ā±ā3.4 |
Ā % TEMRA | 5.4ā±ā1.2 | 4.3ā±ā1 | 3.3ā±ā1.2 | 2.7ā±ā0.4 |
Ā % CD28ā | 1.5ā±ā0.6 | 1.7ā±ā0.4 | 1.1ā±ā0.4 | 1.3ā±ā0.4 |
Ā % CD69+ | 0.2ā±ā0.1 | 15.3ā±ā1.9 | 0.4ā±ā0.2 | 15.2ā±ā2.5 |
Ā % Treg | 3ā±ā0.4 | 3.3ā±ā0.7 | 3.5ā±ā0.9 | 3ā±ā0.4 |
Ā % IFN-γ+ | 19.2ā±ā3.4 | 31.7ā±ā6 | 10.1ā±ā1.9 | 21.2ā±ā6.2 |
Ā % IL-4+ | 3.7ā±ā1.1 | 3.4ā±ā0.9 | 2.4ā±ā0.7 | 1.6ā±ā0.7 |
Ā % IL-2+ | 59.7ā±ā5.1 | 47.4ā±ā8.7 | 55.1ā±ā5.7 | 32.5ā±ā8.3 |
Ā % IL-10+ | 0.38ā±ā0.06 | 1.6ā±ā0.6 | 0.29ā±ā0.05 | 1.7ā±ā0.2 |
Ā % IL-17A+ | 0.34ā±ā0.11 | 0.67ā±ā0.32 | 0.77ā±ā0.12 | 1.14ā±ā0.16 |
Ā % IL-17A+ IFN-γ+ | 0.01ā±ā0.004 | 0.14ā±ā0.06 | 0.09ā±ā0.05 | 0.39ā±ā0.08 |
Ā % polyfunctional | 10.9ā±ā1.3 | 19.8ā±ā4.2 | 6.3ā±ā1.3 | 10.8ā±ā6.6 |
CD8 + T cells | ||||
Ā % TN | 14.8ā±ā5.5 | 6.3ā±ā0.9 | 12.3ā±ā2.4 | 8.6ā±ā1.3 |
Ā % TCM | 15.3ā±ā2.6 | 12.3ā±ā3.9 | 19.9ā±ā3.9 | 14ā±ā1.7 |
Ā % TEM | 37.2ā±ā6.1 | 51.6ā±ā2.4 | 38.2ā±ā7.2 | 50.5ā±ā3.9 |
Ā % TEMRA | 32.7ā±ā4.5 | 29.7ā±ā5 | 29.6ā±ā4.6 | 26.9ā±ā3.4 |
Ā % CD28ā | 46.7ā±ā9.8 | 32.5ā±ā4.1 | 43.2ā±ā10.5 | 32.3ā±ā6.1 |
Ā % CD28ā CD57+ | 28.1ā±ā10.8 | 6.5ā±ā3.1 | 33.5ā±ā8.9 | 11.5ā±ā4.9 |
Ā % CD69+ | 1.1ā±ā0.3 | 44.4ā±ā5.8 | 1.5ā±ā0.3 | 52.1ā±ā5.6 |
Ā % IFN-γ+ | 47.8ā±ā10.4 | 54ā±ā9.6 | 49.7ā±ā9.5 | 64.2ā±ā11.3 |
Ā % IL-2+ | 22.1ā±ā6.6 | 21.4ā±ā7.1 | 19.6ā±ā5.5 | 22.1ā±ā7.6 |
Ā % polyfunctional | 13.9ā±ā2.8 | 19.3ā±ā4.3 | 11ā±ā3.5 | 22.9ā±ā1.6 |