Figure 5
From: Crystal structure of the DNA-binding domain of Myelin-gene Regulatory Factor
The electrostatic surface of MyRF DBD and the superposition of MyRF DBD with Ndt80 shows potential DNA binding region. (A) The electrostatic surface potential of MyRF DBD shows the electropositive region for potential DNA binding. The NH2- (N) and the –COOH (C) terminus of MyRF DBD are marked. (B) Superposition of MyRF DBD and Ndt80 shows the region that may be involved in the interaction between MyRF DBD and its target DNA. The residues K399, R454, R478 (MyRF) and R111, R177, R254 (Ndt80) are shown as a sphere model. MyRF DBD and Ndt80 colored in ice blue and gold respectively. (C) The modeling of MyRF DBD trimer binding with its target DNA. The DNA molecules are shown as a sphere model.
