Figure 6
From: Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole
6OTD suppresses GSC growth in vivo. (A) Effect of 6OTD on intracranial growth of GSCs in a mouse xenograft model. Each mouse was injected with 1.0% DMSO (vehicle) or 6OTD (10 or 100 pmol) intracranially on the same day as the GSC transplantation. n = 5 (vehicle) or 6 (6OTD-treated). Immunohistochemistry of mouse brains stained with human-specific anti-vimentin (top) or anti-nestin (bottom) antibodies. Original magnification of the images was 4×. Graphs indicate the relative tumor size as determined by immunohistochemistry with the glioma markers described above. Error bars indicate the SD values (**P < 0.01). (B) Body weight change of vehicle and 6OTD- (10 or 100 pmol) treated groups.
