Figure 5

Elevated expression of integrin, MMP9, and phosphodiesterase (PDE) in TMD cells. (A,B) Elevated integrin β subunits (B3, B4, B5, and B8) in TMD cells. (C,D) Messenger RNA level and activity of MMP9. (E) Comparison of the mRNA levels of the selected PDEs (8B, 1C, 4B, and 5A) in TMD and BMD cells. (F) Reduction in the mRNA levels of the selected PDEs in TMD cells by GRM3 siRNA. NC = non-specific control siRNA.