Figure 1
From: Clinical Features and Sleep Analysis of Chinese Patients with Fatal Familial Insomnia
The pedigree of case 1(II-7) and case 2(II-9). II-7 is the proband of this pedigree (arrow). II-7 and II-9 are respectively Patient 1 and Patient 2 who carried PRNP D178N mutation. Additionally, seven family members were screened for PRNP gene mutation: II-6, III-6, III-11, III-13, and III-14 were healthy participant free of PRNP D178N mutation; III-10 and III-15 were clinically healthy carriers of the PRNP D178N mutation. Other family members were not screened due to lack of consent or prior death.
