Table 4 Inhibitory effects of compounds 1–16 on NO production induced by LPS in macrophages.

From: Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities

compound

IC50 (mean ± SD, μM)

compound

IC50 (mean ± SD, μM)

1

19.72 ± 1.16

10

0.32 ± 0.14

2

>100

11

>100

3

12.83 ± 0.93

12

78.87 ± 5.01

4

34.19 ± 2.26

13

3.01 ± 0.20

5

69.81 ± 4.44

14

25.91 ± 1.53

6

>100

15

70.69 ± 4.93

7

>100

16

4.03 ± 0.26

8

54.06 ± 3.89

hydrocortisonea

58.79 ± 3.32

9

0.88 ± 0.22

  
  1. aPositive control.
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