Figure 6 | Scientific Reports

Figure 6

From: Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Figure 6

β cell DNA damage to induce p53 activation leads to global reductions in mRNA translation. MIN-6 cells were treated with doxorubicin to directly induce DNA damage. (a) Protein levels of both total and phospho-p53 were assayed after 12 hours of treatment with doxorubicin. (b) Global PRP analysis after 48 hours of doxorubicin treatment.

Back to article page