Table 4 PK-PD modeling of ex vivo cyadox after oral administration at a dose of 30 mg/kg.
From: Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine
Parameters | Units | Values |
|---|---|---|
Emax | Log CFU/mL | 2.71 ± 0.37 |
E0 | Log CFU/mL | −4.61 ± 0.69 |
Emax−E0 | Log CFU/mL | 7.32 ± 1.06 |
EC50 | h | 30.07 ± 6.94 |
N (slope) | / | 4.62 ± 0.72 |
AUC24h/MIC for bacteriostatic effect | h | 26.72 ± 6.28 |
AUC24h/MIC for bactericidal effect | h | 39.54 ± 7.31 |
AUC24h/MIC for eradication effect | h | 50.69 ± 9.16 |
