Figure 7 | Scientific Reports

Figure 7

From: HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Figure 7

The schematic representation of the findings of this study. HIF-1α- induced PDK1 sequesters glucose metabolite flux from the mitochondria to glycolysis. This glycolytic shift redirects the metabolic flux to compensate the suppression of mitochondrial activity by lidocaine to reduce ROS generation and maintain intracellular ATP contents. LDHA: lactate dehydrogenase A, PDH: pyruvate dehydrogenase, PDK1: pyruvate dehydrogenase kinase, ROS: reactive oxygen species.

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