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Figure 1

From: The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages

Figure 1

ABX464 treatment suppresses disease severity in DSS-induced colitis. (a) C57BL/6 mice (n = 12 each cohort) subjected to the DSS colitis protocol shown received orally once a day ABX464 (50 mg/kg) in methylcellulose or methylcellulose only through gavage. (b) Weight development in ABX464 and methycellulose (MC) only treated mice during DSS-induced colitis. Control cohorts included mice not exposed to DSS. (c–e) At the end of the protocol described in (a) mice were sacrificed and colons were analyzed by histology for colitis severity including number of lesion (c), lesion size (d) and colon size (e).

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