Figure 2
The protective effect of ABX464 is maintained in mice during continuous DSS-exposure. (a) C57BL/6 mice (n = 8 each cohort) were challenged with DSS for 63 days. Mice received orally once a day ABX464 in methylcellulose during the whole protocol (group 1) or only for the first 20 days followed by methylcellulose only administration (group 2). Mice of group 3 received methylcellulose during DSS-exposure and had to be scarified at day 10. (b) Weight development in ABX464-treated mice during DSS-administration. (c,d) Colons were analyzed by histology for lesion size (c) and colitis severity (d) at the end of the protocol. Histological scoring was performed as described in the Material and Methods section and detailed in Supplementary Table 1. (e) Representative images for normal colon, crypt abscesses and crypt loss, the latter two being part of the histological scoring shown in 2d. Normal histology of the colon (normal colon); Mucosa, M, composed of epithelial crypt cells, C, underlined by lamina propria, LP; Submucosae, SM; Musculae, Mus; Serosa, S.
