Figure 1 | Scientific Reports

Figure 1

From: Resistin promotes the abnormal Type I collagen phenotype of subchondral bone in obese patients with end stage hip osteoarthritis

Figure 1

Comparison of the structural composition of femoral head subchondral bone in patients of different BMI cohorts. (A) The quantification of the α1/α2 Type I collagen ratio in femoral head subchondral bone. NW = normal-weight (n = 7), OW/OB = overweight/obese (n = 13). Bars represent mean α1/α2 values ± SEM as determined through ImageJ. The gel image is a representative coomassie-stained SDS PAGE gel of a NW OA and OW/OB OA femoral head, demonstrating the separation of α1/α2 type I collagen isoforms. (B) Representation of the area from the trabecular bone for micro-CT analysis. The area analysed was a 1 cm3 from the most medial aspect of the femoral head (as indicated by the red square on the femoral head). Dashed line box = region of interest which was reconstructed for bone parameter analysis.

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