Figure 2
From: Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
Adiponectin knockout mice develop exaggerated dermal fibrosis upon bleomycin treatment. Adiponectinknockout (APN KO) and wildtype (WT) mice received daily s.c. injections of bleomycin (BLM) or PBS (control) for 14 days and lesional skin was harvested for analysis. (a) Left panel, Masson’s Trichrome stain; representative images; scale bar = 100 µm. Right panel, dermal thickness, mean ± SD from seven determinations from 4–8 mice per experimental group. (b) αSMA+ cells were counted in five hpf/slide. Results are means ± SD.
