Figure 7 | Scientific Reports

Figure 7

From: LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine

Figure 7

TONs of the probe substrates metabolized by SULT enzymes in healthy donors, HCC tumors, and match pericarcinomatous tissues, thereby, indicating the catalytic efficiency of enzymes. There is one concentration of probe substrate activities for each SULT, as follow: 1 μM p-nitrophenol for SULT1A1, 0.625 μM dopamine for SULT1A3, 2.5 μM 2-aminophenol for SULT1B1, 10 μM 17β-estradiol for SULT1E1, and 1 μM DHEA for SULT2A1. It is defined as the number of substrate molecules that can be converted by enzyme proteins into products per unit of time. Paired sample t-test or Wilcoxon’s sign rank test was used for data analysis. “*”Denotes statistical significance (P < 0.05).

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