Figure 1 | Scientific Reports

Figure 1

From: A Dynamical Model for Activating and Silencing the Mitotic Checkpoint

Figure 1

Schematic illustration of SAC activity. Unattached kinetochores (red in the middle of the chromosomes) catalyze the formation of MCC which inhibits the Cdc20-activated APC/C. Once all kinetochores are attached (green) the APC/C ubiquitinates Securin and CyclinB, resulting in the destruction of Cohesin by Separase. Unblocked Cdk1 initiates metaphase and progress in the cell cycle.

Back to article page