Figure 8
From: Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression
Inhibition of RBM47 induces metastasis. Formation of lung metastases after tail-vein injection of DLD-1–Luc2 cells transfected with control or RBM47-specific siRNA. (a) Representative images of luciferase signals after D-luciferin injection at the indicated time points after xenografting. (b) Weekly measurements of total photon flux. Results are the mean ± SD (n = 5). **P < 0.01. (c) Representative lungs 8 weeks after tail vein injection. (d) H&E staining of lung tissue. Scale bars represent 500 μm. (e) Number of metastatic nodules in lungs 8 weeks after tail vein injection of the indicated DLD1 cells into mice (n = 5). (f) Model of regulation of RBM47 expression and its downstream targets, which presumably mediate its effects on EMT and cancer progression.
