Table 2 Splenic cell subsets in SIRT3+/+ and SIRT3−/− mice.

From: Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

 

SIRT3+/+

SIRT3−/−

CD3+ T cells (%)

27.3 ± 4.6

31.1 ± 1.0

  CD4+

62.3 ± 2.7

61.2 ± 4.2

  CD4+ CD44low CD62Lhigh (naive)

46.0 ± 4.2

48.9 ± 6.8

  CD4+ CD44high CD62Llow (memory)

16.2 ± 2.6

12.0 ± 2.8

  CD8+

31.5 ± 2.0

32.5 ± 3.3

   CD8+ CD44low CD62Lhigh (naive)

23.3 ± 1.0

28.6 ± 1.7

  CD8+ CD44high CD62Llow (memory)

8.2 ± 0.5

6.6 ± 0.3

  CD4 CD8

1.3 ± 0.1

1.5 ± 0.3

B220+ B cells (%)

50.5 ± 7.6

53.3 ± 3.1

  B220+ IgD+ CD23+ (mature)

45.7 ± 2.6

48.8 ± 2.7

  B220+, non-IgD+/CD23+ (immature)

6.5 ± 0.5

6.4 ± 0.5

CD11c+ DCs (%)

6.2 ± 0.5

6.5 ± 0.6

  B220

62.8 ± 2.5

59.4 ± 2.6

  B220+

37.2 ± 2.5

40.6 ± 2.6

  1. Data are means ± SD of 4 animals per group and expressed as the percentage of CD3+, B220+, and CD11c+ splenic cells or the percentage of the CD3+, B220+ and CD11c+ parental populations expressing CD4, CD8, CD44, CD62L, IgD and CD23. Total cell numbers were 75.1 ± 7.5 and 75.4 ± 21.1 millions per spleen in SIRT3+/+ and SIRT3−/− mice, respectively. No statistically significant differences in subset’s percentages and absolute numbers were detected.