Figure 5
From: Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit
P301L hTau transduction in MEC decreases the probability of presynaptic transmitter release. (A) Microdialysis results indicated the lactate level was significantly reduced. (B,C) The levels of dopamine and 5-HIAA (monoamine neurotransmitter or the metabolites) were also decreased in the intercellular space, while the levels of Ala, Hva, Gly, Glu and GABA were not changed (D–H). (n = 6 per group, *p < 0.05). (I) Input-output curve of the EC-DG perforant path fibers. (J) Mutant P301L hTau produced a decrease of PPF in PP-DG pathway (n = 3 per group, 9 slices, **p < 0.01). Data were expressed as mean ± SEM.
