Figure 1
From: Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model
Mouse model of severe influenza virus infection. (a) Body weight loss, and (b) survival of BALB/c mice following intranasal infection with stated doses of PR8 strain of H1N1 influenza virus. (c) Lung virus titer on the stated days post infection with indicated doses of PR8 influenza virus infection in BALB/c mice of same age group. (d) Pathological analysis of lung tissue sections (Left panel) and gross lung pathology (Right panel) of BALB/c mice on day 7- post infection following infection with 2.5 × 103 PFU of PR8 influenza virus. Data are representative of at least three similar experiments and presented as mean ± s.d. (***p < 0.0001; **p < 0.001; NS = non-significant, p > 0.05; n = 6/group).
