Figure 2
From: Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model
Protective effect of Oseltamivir disappears with delayed treatment onset. Early treatment of Oseltamivir effectively prevented disease of sub-lethal (a, inoculum dose = 2.5 × 103 PFU) and lethal (b, inoculum dose = 1.25 × 104 PFU) PR8 influenza virus infection in BALB/c mice. The protection decreases with delay of treatment and there was almost no protection with treatment from day 3- post infection. Naïve mice of comparable age were infected with stated inoculum size of PR8 virus. Control untreated mice received daily oral feeding of equal volume phosphate buffered saline (PBS) starting from the stated days post infection of the influenza virus. Data are representative of at least three similar experiments and presented as mean ± s.d. (***p < 0.0001; **p < 0.001; *p < 0.01; NS = non-significant, p > 0.05; n = 6/group).
