Figure 7
The change in the aggregation pathway for BSA aggregation in the presence of Arg and its derivatives. (A) The dependences of the hydrodynamic radius (R h) of BSA aggregates on the portion of the aggregated protein (γagg) calculated at different concentrations of Arg: 0 (1), 50 (2), 350 (3) and 700 mM (4). (B) The dependences of R h of BSA aggregates on γagg calculated at different concentrations of ArgAd: 0 (1), 50 (2), 200 (3) and 700 mM (4). (C) The dependences of R h of BSA aggregates on γagg calculated at different concentrations of ArgEE: 0 (1), 50 (2), 200 (3) and 1000 mM (4). (D) The dependences of the relative values of the initial slopes (dR h/dγagg)/(dR h/dγagg)0 on the concentration of Arg, ArgAd and ArgEE. (dR h/dγagg)0 and (dR h/dγagg) are the initial slopes of the dependences of R h on γagg calculated in the absence or in the presence of additives, respectively. Three independent measurements were used to determine the error bars shown in this figure.
