Table 2 Differentially abundant serum proteins identified in longitudinal cohorts of vivax malaria patients.

From: Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection

Sl NO.

Protein name

Uniprot Accession ID

Gene Name

Unique peptides†

(FEB/HC)

(DEF/HC)

(CON/HC)

Fold-change

Adjusted p-value

Fold-change

Adjusted p-value

Fold-change

Adjusted p-value

1

Apolipoprotein A-II

P02652

APOA2

8

0.41

0.047

0.47

0.073

0.64

0.244

2

Apolipoprotein A-I$*

P02647

APOA1

36

0.42

0.001

0.48

0.008

0.64

0.054

3

Heparin cofactor 2

P05546

SERPIND1

7

0.44

0.005

0.39

0.001

0.50

0.019

4

Apolipoprotein C-I

P02654

APOC1

3

0.45

0.003

0.40

0.00003

0.46

0.0002

5

Haptoglobin$*

P00738

HP

17

0.47

0.024

0.68

0.049

1.09

0.704

6

Inter-alpha-trypsin inhibitor heavy chain H2$

P19823

ITIH2

18

0.49

0.008

0.41

0.003

0.51

0.025

7

Serum paraoxonase/ arylesterase 1

P27169

PON1

5

0.64

0.074

0.54

0.007

0.69

0.122

8

Inter-alpha-trypsin inhibitor heavy chain H1

P19827

ITIH1

15

0.65

0.021

0.45

0.000

0.66

0.013

9

Conserved oligomeric Golgi complex subunit 4

Q9H9E3

COG4

8

0.66

0.148

0.55

0.018

0.85

0.360

10

Afamin

P43652

AFM

13

0.67

0.033

0.73

0.131

0.64

0.021

11

Apolipoprotein C-III

P02656

APOC3

5

0.68

0.031

0.68

0.041

0.73

0.209

12

Kininogen-1

P01042

KNG1

6

0.69

0.081

0.63

0.006

0.68

0.113

13

Fibronectin

P02751

FN1

22

0.72

0.030

0.58

0.005

0.63

0.009

14

Inter-alpha-trypsin inhibitor heavy chain H4

Q14624

ITIH4

24

0.72

0.043

0.63

0.056

0.71

0.035

15

Complement C5

P01031

C5

8

0.73

0.067

0.67

0.038

0.68

0.023

16

Complement C3

P01024

C3

89

0.74

0.159

0.66

0.032

0.79

0.171

17

Clusterin

P10909

CLU

12

0.75

0.106

0.68

0.003

0.71

0.092

18

Apolipoprotein B-100

P04114

APOB

145

0.77

0.030

0.63

0.002

0.76

0.029

19

Serum amyloid P-component

P02743

APCS

3

0.78

0.216

0.62

0.025

0.70

0.086

20

Complement C4-A

P0C0L4

C4A

7

0.85

0.104

0.73

0.014

1.10

0.703

21

Hemopexin$*

P02790

HPX

12

1.22

0.05

1.12

0.163

1.00

0.295

22

Apolipoprotein E*

P02649

APOE

11

1.24

0.05

1.16

0.045

0.87

0.715

23

Alpha-1-acid glycoprotein 1

P02763

ORM1

8

1.25

0.139

1.49

0.041

1.46

0.088

24

Biotinidase

P43251

BTD

2

1.30

0.045

1.12

0.555

1.10

0.685

25

Alpha-1-antichymotrypsin$

P01011

SERPINA3

26

1.42

0.036

1.28

0.379

1.22

0.096

26

Alpha-1-antitrypsin$

P01009

SERPINA1

40

1.47

0.115

1.51

0.004

1.50

0.164

27

Leucine-rich alpha-2-glycoprotein$

P02750

LRG1

7

1.83

0.005

1.63

0.037

1.49

0.047

28

Cell growth-regulating nucleolar protein

Q9NX58

LYAR

13

1.85

0.056

2.10

0.044

2.26

0.157

29

Serum amyloid A-1$*

P0DJI8

SAA1

6

2.49

0.008

1.60

0.023

2.15

0.018

30

Carbonic anhydrase 1

P00915

CA1

4

2.61

0.014

1.37

0.207

1.43

0.048

31

Hemoglobin subunit alpha

P69905

HBA1

7

2.63

0.006

1.49

0.025

1.33

0.032

32

Hemoglobin subunit beta

P68871

HBB

8

2.70

0.003

1.66

0.057

1.47

0.047

33

Hemoglobin subunit delta

P02042

HBD

7

3.77

0.005

1.89

0.101

1.83

0.036

34

C-reactive protein

P02741

CRP

4

3.91

0.003

6.69

0.006

2.45

0.001

35

Hemoglobin subunit zeta

P02008

HBZ

5

4.83

0.011

1.88

0.023

2.21

0.041

  1. #This is a partial list for some selected candidates (p < 0.05 in at least one comparison) identified in iTRAQ and 2D-DIGE-based quantitative proteomics analysis; complete lists of the identified differentially abundant proteins are provided under supplementary information (Tables S6, S7 and S8). †Median value for the identified unique peptides in different biological replicates is represented. $Differential abundances for these candidates are also identified in 2D-DIGE (details are provided in Table S6). *Differential serum abundances of these proteins are validated by ELISA (details are provided in Table S13A).
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