Table 7 Regression analysis of the factors associated with survival in patients who received R-CHOP 21 (n = 286).
From: Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
Univariate analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
Hazard Ratio | 95% CI p value | Hazard Ratio | 95% CI p value | ||
Age | <65 years | 1.00 | 1.00 | ||
>65 years | 2.21 | 1.42 to 3.42 p = <0.001 | 1.32 | 0.75 to 2.30 p = 0.328 | |
Sex | Female | 1.00 | 1.00 | ||
Male | 1.19 | 0.77 to 1.82 p = 0.421 | 1.49 | 0.91 to 2.44 p = 0.112 | |
Charlson Comorbidity Score | 1–2 | 1.00 | 1.00 | ||
3–5 | 5.14 | 3.03 to 8.74 p = <0.001 | 4.12 | 2.32 to 7.33 p = <0.0001 | |
6+ | 13.88 | 7.03 to 27.41 p = <0.001 | 11.02 | 4.99 to 24.34 p = <0.0001 | |
ECOG | 0 | 1.00 | 1.00 | ||
1 | 4.07 | 1.69 to 9.78 p = <0.002 | 2.69 | 1.00 to 7.26 p = 0.050 | |
2 | 8.30 | 3.46 to 19.89 p = <0.001 | 2.97 | 1.27 to 12.41 p = 0.018 | |
3 and 4 | 19.83 | 7.49 to 52.64 p = <0.001 | 7.16 | 2.04 to 25.06 p = 0.002 | |
Stage | 1 | 1.00 | 1.00 | ||
2 | 1.29 | 0.51 to 3.24 p = 0.583 | 1.25 | 0.44 to 3.54 p = 0.665 | |
3 | 1.56 | 0.58 to 4.16 p = 0.37 | 1.17 | 0.365 to 3.80 p = 0.78 | |
4 | 2.43 | 1.04 to 5.66 p = 0.039 | 1.22 | 0.399 to 3.73 p = 0.72 | |
NCCN IPI | Low risk | 1.00 | |||
Low intermediate | 1.00 | 1.00 | |||
High intermediate | 1.35 | 0.80 to 2.27 p = 0.256 | 0.88 | 0.39 to 1.99 p = 0.76 | |
High | 2.61 | 1.54 to 4.40 p = <0.001 | 1.82 | 0.63 to 5.22 p = 0.26 | |
Number of chemotherapy cycles | 1–2 | 1.00 | |||
3–4 | 0.13 | 0.062 to 0.27 p = <0.0001 | 0.27 | 0.11 to 0.68 p = 0.005 | |
5–6 | 0.08 | 0.04 to 0.15 p = <0.0001 | 0.09 | 0.041 to 0.19 p = <0.0001 | |
>6 | 0.10 | 0.03 to 0.34 p = <0.0001 | 0.11 | 0.03 to 0.40 p = <0.0001 | |
Creatinine | Normal | 1.00 | 1.00 | ||
Raised | 1.27 | 0.82 to 1.96 p = 0.270 | 0.79 | 0.44 to 1.43 p = 0.45 | |
Neutropenia within 48 hours of admission with infection | No | 1.00 | 1.00 | ||
Yes | 4.92 | 2.82 to 8.58 p = <0.0001 | 3.15 | 1.66 to 5.96 p = <0.0001 | |
Pegfilgrastim w/I 21 days of admission with infection | No | 1.00 | 1.00 | ||
Yes | 0.82 | 0.50 to 1.10 p = 0.449 | 1.26 | 0.72 to 2.21 p = 0.40 | |
Admission with infection | No | 1.00 | No | 1.00 | |
Yes | 1.63 | 1.94 to 6.65 p = <0.0001 | 3.27 | 1.00 to 2.63 p = <0.046 | |
