Figure 2 | Scientific Reports

Figure 2

From: PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

Figure 2

Changes of parthanatos-related proteins caused by cadmium. Western blot analysis of the expression of parthanatos-related proteins in NRK-52E cells and primary rPT cells after treated with different concentrations of Cd for 12 h. (A and B) Cytoplasmic and nuclear PARP-1 and nuclear AIF increased as the Cd concentration and incubation time increased in NRK-52E cells and primary rPT cells. (C and D) Cd induced the cytoplasmic formation of PAR polymer, dependent on its concentration and exposure time in NRK-52E cells and primary rPT cells.

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