Figure 9 | Scientific Reports

Figure 9

From: PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

Figure 9

Cd-induced oxidative stress and the effect of parthanatos on reactive oxygen species (ROS) in cells. (A) NAC significantly reduced the expression of related apoptotic proteins in primary rPT cells. (B) NAC attenuates the effect of Cd on NRK-52E cells proliferation. (C) AO-EB staining showed that NAC significantly reduced the Cd-induced cell apoptosis and death (200×). (D) Inhibition of PARP-1 overexpression or silencing its gene reduced the ROS content obviously.

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