Figure 2
From: Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P
Interplay between AG and supplemental selenite on SELENOP concentrations. HepG2 cells were incubated for 48 h in the presence of G418 or gentamicin with or without supplemental selenite (100 nM). Secreted SELENOP (SEPP1) was quantified by ELISA analyses. G418 strongly induced SELENOP concentrations in the conditioned medium, whereas gentamicin showed no effect. The effect of G418 was augmented by supplemental selenite. (Mean ± SEM, n = 6, ANOVA followed by Dunnett’s).
