Figure 3

Brain activity changes associated with oxaliplatin-induced cold hypersensitivity. Three days after oxaliplatin infusion, increased activation in the secondary somatosensory cortex (SII) and the insular cortex (Ins) in both hemispheres, compared with activation before oxaliplatin infusion (“Intact”) (c.f. Table 1), were associated with low-temperature stimulation (i.e., activity in response to 10 °C stimulation minus activity in response to 37 °C (control) stimulation). (a) Results of subject-level analysis. Increased activation in SII/Ins (arrows) is observed in all four oxaliplatin-treated macaques. (b) Results of group-level analysis. A series of coronal slices, spaced 2 mm apart, are arranged from rostral (upper left, y = 24) to caudal (lower right, y = −10). Cb, cerebellum. (c) Peak voxels were located in the anterior SII/Ins of both hemispheres (arrows). The arrows indicate peak voxels in each hemisphere.